Tesofensine
to clear
How a single dose clears, assuming first-order elimination. The half-life is the biggest driver of how often you dose — start a cycle to see your own cumulative concentration curve.
An oral triple monoamine-reuptake inhibitor investigated for obesity, producing notable appetite suppression.
Inhibits reuptake of dopamine, noradrenaline, and serotonin, reducing appetite and increasing satiety.
0.25–1 mg orally once daily; long half-life means slow accumulation.
Room temp, dry.
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Semaglutide
A long-acting GLP-1 receptor agonist for type-2 diabetes and weight management. Slows gastric emptying and suppresses appetite.
Tirzepatide
A dual GIP/GLP-1 receptor agonist with superior weight loss and glycemic control versus semaglutide in head-to-head trials.
Retatrutide
An investigational triple agonist (GIP/GLP-1/glucagon) showing the largest weight-loss figures yet in trials. Not yet approved.