Compound atlas
Cognitive

PE 22-28

Peptide
Half-life
1h
approx. mean t½
Dose range
200–400 mcg
typical, not prescriptive
Category
Cognitive
primary use-case
Single-dose decay
t½ = 1h · first-order model
~4h
to clear
1× t½
50%
remaining
2× t½
25%
remaining
~4× t½
6%
remaining
0%25%50%75%100%0m1.2h2.4h3.6h4.8h6h

How a single dose clears, assuming first-order elimination. The half-life is the biggest driver of how often you dose — start a cycle to see your own cumulative concentration curve.

Overview

A spadin-derived peptide investigated for fast-acting antidepressant and neurogenic effects.

Mechanism of action

Blocks TREK-1 potassium channels, a pathway linked to rapid antidepressant action and neurogenesis.

Typical protocol

200–400 mcg intranasal daily in short cycles.

Storage

Refrigerated; nasal solution ~30 days.

Disclaimer

This page summarizes publicly available information. None of it constitutes medical advice, prescription, or recommendation to acquire, possess, or use any compound. Many peptides described are research chemicals not approved for human use in the EU. Consult a licensed physician.